2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1080R
    Tilorone dihydrochloride (Standard) 27591-69-1 98%
    Tilorone (dihydrochloride) (Standard) is the analytical standard of Tilorone (dihydrochloride). This product is intended for research and analytical applications. Tilorone dihydrochloride is an orally active interferon (IFN) inducer with broad-spectrum antiviral activities. Tilorone dihydrochloride possesses robust anti-Severe fever with thrombocytopenia syndrome virus (SFTSV) activity in vitro and in vivo through stimulation of host innate immunity. Tilorone dihydrochloride can penetrate the blood-brain barrier to activate HIF in the CNS.Tilorone dihydrochloride exhibits an inhibitory activity with EC50 of 230 nM against Ebola virus (EBOV).
    Tilorone dihydrochloride (Standard)
  • HY-B1086R
    Afalanine (Standard) 2901-75-9 98%
    Afalanine (Standard) is the analytical standard of Afalanine. This product is intended for research and analytical applications. Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. Afalanine can be used in combination with antibiotics to prevent renal damage.
    Afalanine (Standard)
  • HY-B1110R
    Nomifensine (Standard) 24526-64-5 98%
    Nomifensine (Standard) is the analytical standard of Nomifensine. This product is intended for research and analytical applications. Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research.
    Nomifensine (Standard)
  • HY-B1124R
    Fipexide (Standard) 34161-24-5
    Fipexide (Standard) is the analytical standard of Fipexide. This product is intended for research and analytical applications. Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.
    Fipexide (Standard)
  • HY-B1139R
    Tolperisone hydrochloride (Standard) 3644-61-9 98%
    Tolperisone (hydrochloride) (Standard) is the analytical standard of Tolperisone (hydrochloride). This product is intended for research and analytical applications. Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity.
    Tolperisone hydrochloride (Standard)
  • HY-B1154R
    Penbutolol sulfate (Standard) 38363-32-5 98%
    Penbutolol (sulfate) (Standard) is the analytical standard of Penbutolol (sulfate). This product is intended for research and analytical applications. Penbutolol sulfate ((-)-Terbuclomine) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3.
    Penbutolol sulfate (Standard)
  • HY-B1173R
    (+)-Camphor (Standard) 464-49-3
    (+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation.
    (+)-Camphor (Standard)
  • HY-B1179R
    Dipyrocetyl (Standard) 486-79-3 98%
    Dipyrocetyl (Standard) is the analytical standard of Dipyrocetyl. This product is intended for research and analytical applications. Dipyrocetyl is a Salicylic Acid (HY-B0167) derivative, exhibiting analgesic and antipyretic activity. Dipyrocetyl can be used for inflammation diseases and pain.
    Dipyrocetyl (Standard)
  • HY-B1180R
    Vinburnine (Standard) 4880-88-0
    Vinburnine (Standard) is the analytical standard of Vinburnine. This product is intended for research and analytical applications. 0
    Vinburnine (Standard)
  • HY-B1184R
    Mephenytoin (Standard) 50-12-4 98%
    Mephenytoin (Standard) is the analytical standard of Mephenytoin. This product is intended for research and analytical applications. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate.
    Mephenytoin (Standard)
  • HY-B1184S
    Mephenytoin-d3 1185101-86-3 99.52%
    (Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate.
    Mephenytoin-d3
  • HY-B1185R
    Beclamide (Standard) 501-68-8
    Beclamide (Standard) is the analytical standard of Beclamide. This product is intended for research and analytical applications. Beclamide is an active molecule with anticonvulsant activity, used as an anticonvulsant drug.
    Beclamide (Standard)
  • HY-B1200R
    Pralidoxime chloride (Standard) 51-15-0 98%
    Pralidoxime (chloride) (Standard) is the analytical standard of Pralidoxime (chloride). This product is intended for research and analytical applications. Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning.
    Pralidoxime chloride (Standard)
  • HY-B1213S
    Trimipramine-d3 maleate 1185245-93-5 98%
    Trimipramine-d3 (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively.
    Trimipramine-d3 maleate
  • HY-B1215R
    Dimenhydrinate (Standard) 523-87-5 98%
    Dimenhydrinate (Standard) is the analytical standard of Dimenhydrinate. This product is intended for research and analytical applications. Dimenhydrinate is an orally active H1-antihistamine consisting of Diphenhydramine (HY-B0303) and 8-Chlorotheophylline. Dimenhydrinate is used to prevent nausea, vomiting, dizziness, and vertigo associated with motion sickness.
    Dimenhydrinate (Standard)
  • HY-B1216R
    Oxeladin citrate (Standard) 52432-72-1
    Oxeladin (citrate) (Standard) is the analytical standard of Oxeladin (citrate). This product is intended for research and analytical applications. Oxeladin citrate is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM). Oxeladin can be used for pulmonary diseases and stroke research.
    Oxeladin citrate (Standard)
  • HY-B1223R
    Anethole trithione (Standard) 532-11-6 98%
    Anethole trithione (Standard) is the analytical standard of Anethole trithione. This product is intended for research and analytical applications. Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research.
    Anethole trithione (Standard)
  • HY-B1225S
    Promazine-d6 hydrochloride 1246819-33-9 98%
    Promazine-d6 (hydrochloride) (Romtiazin-d6 (hydrochloride)) is deuterium labeled Promazine (hydrochloride). Promazine (Romtiazin) hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist. Promazine hydrochloride inhibits dopaminergic neurotransmission.
    Promazine-d6 hydrochloride
  • HY-B1232R
    Metyrapone (Standard) 54-36-4 98%
    Metyrapone (Standard) is the analytical standard of Metyrapone. This product is intended for research and analytical applications. Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression.
    Metyrapone (Standard)
  • HY-B1238R
    Pronethalol (Standard) 54-80-8 98%
    Pronethalol (Standard) is the analytical standard of Pronethalol. This product is intended for research and analytical applications. Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs).
    Pronethalol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity